Thursday, November 30, 2017
Partnering with Insmed to Develop Treatments for Rare Diseases
A veteran and recipient of the U.S. Army Achievement Medal, Bryan Jadot has served in various capacities in financial institutions such as Wells Fargo Bank and Silicon Valley Bank. Bryan Jadot is now the senior managing director of life sciences at Hercules Capital, Inc.
Hercules is a business development firm focused on venture lending. One of the firms that Hercules has worked with is Insmed.
Insmed is a venture dedicated to improving the lives of patients battling rare diseases by developing innovative therapies. Hercules began working with Insmed in 2012. Attracted by the company’s experienced management team, sound balance sheet, and solid product, Hercules provided flexible financing to steer Insmed’s progress through the initial stages of the FDA approval process. Afterward, the two companies’ relationship deepened as Hercules gained first-hand experience with the difficulties involved in bringing a new drug to the market.
Hercules continues to be a strong partner of Insmed, providing debt financing to foster its growth and ensure minimal equity dilution for the company's owners. Just last year (2016) Hercules signed a $55 million debt agreement with the company to allow it to refinance its existing debt obligations and enter into a licensing agreement with AstraZeneca, a pharmaceutical giant.
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Saturday, November 11, 2017
Three Tips for Making Perfect Crepes
As the senior managing director of life sciences at Hercules Capital, Inc., Bryan Jadot manages a team of dynamic professionals. Outside of the office, Bryan Jadot enjoys making breakfast for his family, and one of his go-to dishes is crepes.
The perfect crepe is a thin, airy, yet lightly crisp, pancake. Here are three tips for making perfect crepes every time:
1. Refrigerate the batter for an hour or more. Refrigeration helps relax the gluten and makes crepes light and airy.
2. Ensure even heating. Turn on the heat five or six minutes before pouring batter into the pan. Preheating the pan will help make the crepes perfectly uniform and evenly cooked.
3. Experiment with fillings. While a sweet filling like fruit is ideal for breakfast, a savory filling like sausage or seafood can turn the breakfast item into an easy and delicious lunch or dinner.
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Friday, March 24, 2017
Three Life Science Companies Backed by Hercules Capital
A former nuclear operations specialist for the U.S. Army in Europe, Bryan Jadot earned a bachelor's in economics from California State University, Sacramento, before embarking on career in the financial sector. Since 2005, Bryan Jadot has managed debt investments for leading health, wellness, and pharmaceutical companies as the senior managing director for the life sciences division of Hercules Capital Inc.
Hercules Capital's life science portfolio consists of over 100 established and startup companies in sub-sectors such as drug delivery, medical devices, and diagnostics. Below are three businesses which highlight Hercules' diverse portfolio.
1. Aspire Bariatrics is the creator of AspireAssist, a minimally-invasive, FDA-approved weight loss solution. A 15-minute procedure involves placing a thin tube inside the patients' stomach, which connects to a discreetly-placed device outside the abdomen, enabling the stomach to be partially emptied at the user's discretion.
2. Dynavax is a California-based biopharmaceutical company working to develop products to treat autoimmune and inflammatory diseases.
3. Neosil has an expanding catalog of dermatology products, including topical solutions for hair growth and acne.
Monday, February 27, 2017
Golden Rice Addresses Vitamin A Deficiencies
Investment professional Bryan Jadot serves as the senior managing director of the life sciences practice at Hercules Capital. With over 20 years of experience, Bryan Jadot manages investment and lending programs for companies specializing in life sciences. He has a particular interest in the field of biotechnology.
In its most basic form, “biotechnology” refers to technology that is based on biology. Biotechnology has influenced agriculture in numerous ways, as plants are bioengineered to produce greater yields, resist diseases and pests, and reduce negative environmental impact.
In 2004, the first trials of a bioengineered rice called Golden Rice were conducted. Developed by a nonprofit called the International Rice Research Institute, Golden Rice has been engineered to include increased amounts of vitamin A. Experts hope that Golden Rice can be cultivated in areas where high numbers of people suffer from critical vitamin A deficiencies, which can lead to blindness, a weakened immune system, and death.
One bowl of Golden Rice contains 60 percent of a child's daily requirement of vitamin A. Since rice currently serves as a staple food for over half of the world’s population, introducing vitamin A in the form of beta carotene into the genes of rice can make a significant impact on the health of numerous groups.
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